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Deciding to deal with Dren, they go back to the farm, only to discover her body in the water tank, apparently dead. (During her sexual encounter with Clive, Dren reveals that she had regenerated her stinger.) Elsa and Clive have a heated argument about Clive having cheated, when he confronts her having figured out that she used samples of her own DNA in the creation of Dren. Soon after, Clive is seduced by her and has sex with her, much to Elsa's disgust. She cuts off her stinger and uses organic tissue from it to finally isolate and synthesize a protein they had been searching for. Elsa, who had formed a maternal bond with Dren, changes her mind after Dren shows violent behavior, killing her own pet cat out of spite and assaulting her. Meanwhile, Dren has become amphibious, winged and omnivorous with a toxic sting. Following this meeting, N.E.R.D., finds itself in danger of going out of business unless they can find a profitable discovery. This led to a disastrous presentation during a company shareholder meeting, when the two original hybrids, not both male, killed each other in front of shareholders and potential investors. One of the original hybrid animals that they had created, which was originally female, had changed sex unbeknownst to Clive & Elsa since they were distracted. Their work at the company suffers as their attention is focused on Dren. As their lab becomes exceedingly crowded, and the risk of Dren being discovered increases, they move Dren to Elsa's late mother's farm. They name their creature Dren, who exceeds their wildest dreams she begins to grow and learn at an accelerated rate. Though they disagree about actually bringing the hybrid to term, Elsa pushes the issue and she persuades Clive to go along with it, in continued secrecy. Not wishing to spend all their time engaged in what they consider mundane research for the next 5-10 years, Clive and Elsa secretly conduct their own experiments, blending human DNA with that other animals. But the pharmaceutical company that funds their research, N.E.R.D., forbids it, instead mandating that their department be reorganized to focus on finding & extracting certain proteins from the creatures they have already created. Now they want to use human DNA in a hybrid that could revolutionize science and medicine. Superstar genetic engineers Clive Nicoli (Adrien Brody) and Elsa Kast (Sarah Polley) achieve fame by successfully splicing together the DNA of different animals to create incredible new hybrid animals.